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Return to: College of Biological Sciences: Medical School: U of M Home |
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Areas of Research Strength: Regulation Gene Expression Developmental Mechanisms Human Genetics back to top |
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Research Techniques: back to top |
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Research Interests: The Bardwell laboratory is interested in the role of transcription factors in cancer and development. Their work focuses on BCL6 and the DMRT family of transcription factors. In appropriate expression of BCL6 protein leads to the development of diffuse large cell lymphomas. They are investigating the mechanisms of transcriptional repression used by the BCL6 co-repressor, BCOR. The lab is also studying the role of BCOR in the generation of lymphomas and in development, where it has multiple important functions. Some DMRT proteins are important in testis development and may play a role in the generation of cancer. They are investigating their mechanisms of transcriptional regulation. back to top |
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Selected Publications: Kim, S., Namekawa, S.H., Niswander, L.M., Ward, J.O., Lee, J.T., Bardwell, V.J., and Zarkower, D. (2007) A mammal-specific Doublesex homolog required for sex chromatin modification during male meiosis. PLoS Genetics, in press. Fahrioglu, U., Murphy, M.W., Zarkower, D., and Bardwell, V.J. (2007) mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice. Sexual Development 1:42-58. Balciuniene, J., Bardwell, V.J., and Zarkower D. (2006) Mice mutant for the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles. Mol. Cell. Biol. 26:9884-8991. Wamstad, J.A., and Bardwell, V.J. (2007) Characterization of Bcor expression in mouse development. (2007) Gene Expr. Patterns 7:550-557. Arrigoni, R., Alam, S.L., Wamstad, J.A., Bardwell, V.J., Sundquist, W.I. and Schreiber-Agus, N. (2006) The Polycomb-associated protein Rybp is a ubiquitin binding protein. FEBS Lett. 580(26):6233-41. Gearhart, M.D., Corcoran, C.M., Wamstad, J.A. and Bardwell, V.J. (2006) Polycomb Group and SCF ubiquitin ligases are present in a BCL6 corepressor complex. Mol. Cell. Biol. 26(18):6880-6889. Winkler, G.S., Mulder, K.W., Bardwell, V.J., Kalkhoven, E. and Timmers, H.T. (2006) Human Ccr4-Not Complex Is a Ligand-Dependent Repressor of Nuclear Receptor-Mediated Transcription. (2006) EMBO J. 25(13):3089-3099. Ng, D., Thakker, N., Corcoran, C.M., Donnai, D., Perveen, R., Schneider, A., Hadley, D.W., Tifft, C., Zhang, L., Wilkie, A.O, Van Der Smagt, J.J., Gorlin, R.J., Burgess, S.M., Bardwell, V.J., Black, G.C. and Biesecker, L.G. (2004) Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Nat Genet. 36(4):411-416. Chevallier, N., Corcoran, C.M., Lennon, C., Haijek, E., Chadburn, A., Bardwell, V.J., Licht, J.D., Melnick, A. (2004) The ETO Protein of t(8;21) AML is a Corepressor for the Bcl-6 B-cell Lymphoma Oncoprotein. Blood 103(4):1454-63 Volff, J.-N., Zarkower, D., Bardwell, V.J. and Schartl, M. (2003) Evolutionary dynamics of the DM domain gene family in metazoans. Journal of Molecular Evolution. 57:1-9. Kim, S., Kettlewell, J.R., Anderson, R.C., Bardwell, V.J. and Zarkower, D. (2003) Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad. Mechanisms of Development. 3(1):77-82. Raymond, C.S., Murphy, M., O'Sullivan, M.G., Bardwell, V.J. and Zarkower, D. (2000) Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes and Development 14(20):2587-2595. Huynh, K.D., Fischle, W., Verdin, E. and Bardwell, V.J. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes and Development 14(14):1810-1823. Huynh, K.D. and Bardwell, V.J. (1998) The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 17:2473-2483. Book Chapter: Hilton, E., Black, G. and Bardwell, V.J. (2007) The BCL-6 corepressor (BCOR) and Oculofaciocardiodental syndrome. Chapter for the book Inborn Errors of Development, Charles Epstein, Editor, Oxford University Press (in press). To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed search menu should say PubMed type Bardwell VJ in the avaliable line back to top |
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