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Return to: College of Biological Sciences: Medical School: U of M Home |
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Areas of Research Strength: Regulation of Gene Expresison Human Genetics back to top |
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Research Interests: Dr. Berry's major laboratory priority is defining the molecular actions of growth hormone. The lab uses the model of the rat serpin multigene family, as several rat serpins are growth hormone responsive and developmentally expressed. As such, they are useful for investigation of the role(s) that hormones have in influencing the program of orderly gene expression in development. The lab developed the rat Spi 2.1 locus as a model system for the study of growth hormone response: this gene is now the most frequently used and best characterized model for the study of growth hormone action. Having demonstrated the participation of Stat5 in this signal transduction pathway, the lab is now working to expand the Stat5-mediated GH domain of action by antagonism of Stat5. In addition, the serpins respond to acute phase stimuli (inflammation). Several lines of evidence suggest there may be an interaction between this normal physiologic response to stress and growth regulation. Investigation of this interaction may provide new insights into the modulation of growth and the role of serpins in this modulation. In the rat Spi 2 locus there are both negative and positive acute phase reactants, while the promoters for these genes remain highly homologous. This permits a detailed examination of the interaction of both cis and trans factors in the coordinate regulation of the positive and negative responses to inflammation. The lab's current project in this area is defining the role of STAT proteins in the response to inflammation, using the rat Spi 2 gene model. This work currently focuses on the examination of the negative acute phase response evidenced by the growth hormone responsive gene Spi 2.1. Further projects explore the interaction of GH action and inflammation in other acute phase and GH responsive genes. In clinical research activities, Dr. Berry is working with the Region IV Genetics Collaborative to develop long-term follow up studies in the care of children with inborn errors of metabolism. back to top |
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Selected Publications: Thompson DB, Ahrens MJ, LeRoy BS, Brown D, Berry SA: Newborn blood spot screening and genetic services: a survey of Minnesota primary care physicians. Genet Med 7(8): 564-70, 2005 Ensenauer R, Vockley J, Willard JM, Huey JC, Sass JO, Edland SD, Burton BK, Berry SA, Santer R, Grünert S, Koch HG, Marquardt I, Rinaldo P, Hahn S, Matern D: A common mutation is associated with a mild, potentially asymptomatic phenotype in patients with isovaleric acidemia diagnosed by newborn screening. Amer J Hum Genet 75(6): 1136-42, 2004 Wu-Chen WY, Christiansen SP, Berry SA, Engel WK Fray KJ, and Summers CG: Ophthalmic manifestations of Wolf–Hirschhorn syndrome J AAPOS 8:345-348, 2004 Kamat D, Petry L, Berry S: A case of Satoyoshi syndrome: a multisystem disorder. Clin Pediatr (Phila) Oct; 42(8): 745-8, 2003 Matern D, He M, Berry SA, Rinaldo P, Whitley CB, Madsen PP, Van Calcar S, Lussky RC, Andresen BC, Wolff JA, Vockley J: Diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry, Pediatrics 112(1 Pt 1): 74-8, 2003 Gupta PA, Putnam EA, Carmical SG, Kaitila I, Steinmann,B, Child A, Danesino C, Metcalfe K, Berry SA, Chen E, Delorme CV, Thong MK, Ades LC, Milewicz DM: Ten novel FBN2 mutations in congenital contractural arachnodactyly: delineation of the molecular pathogenesis and clinical phenotype. Hum Mutat 19(1): 39-48, 2002 Krishnamurti L, Neglia JP, Nagarajan R, Berry SA, Lohr J, Hirsch B, White JG: Paris-Trousseau platelets in a child with Jacobsen syndrome. Amer J Hematol 66(4): 295-299, 2001 Bergad PL, Schwarzenberg SJ, Amarasinghe S, Humbert JT, Towle HC, Berry SA: Inhibition of growth hormone action in models of inflammation. Am J Physiol, 279:C1906-C1917, 2000 Phornphutkul C, Frick GP, Goodman HM, Berry SA, Gruppuso PA: Hepatic growth hormone signaling in the late gestational fetal rat. Endocrinology 141:3527-3533, 2000 Bergad PL, Towle HC, Berry SA: YY1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the Spi 2.1 gene. J Biol Chem 275(11): 8114-8120, 2000 Humbert JT, Bergad PL, Masha O, Stolz A, Kaul S, Berry SA: Growth hormone action in hypothyroid infant rats. Pediatr Res, 47(2): 250-255, 2000 To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed search menu should say PubMed type Berry SA in the avaliable line back to top |
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Related Links: http://www.med.umn.edu/peds/genetics/faculty/berry/home.html http://www.uofmchildrenshospital.org/Services/Services/c_195840.asp back to top |
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