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Cahterine Kirkpatrick, Ph.D.

Research Associate

Mailing Address:
University of Minnesota
Department of Genetics, Cell Biology, and Development
6-160 Jackson
321 Church St. SE
Minneapolis, MN 55455
USA
Education:
Ph.D. Massachusetts Institute of Technology, 1994

Honors:
Office:
6-129 MCB
P:612-625-3737
F:612-626-5652

Email:
cakirkpa@umn.edu

 Lab:
5-140 Moos
P:622-624-5673

Areas of Research Strength:

Cell-cell signaling
proteoglycans in development
genetics


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Research Interests:

Signaling between cells during development is essential for establishing
the final body plan in multicellular animals. Many signaling pathways,
such as Wnt, BMP and Hedgehog signaling, are regulated by proteoglycans,
which are abundant carbohydrate-modified proteins on cell surfaces and in
the extracellular matrix. The fruit fly Drosophila is an excellent model system
for analyzing proteoglycan function during development. Sophisticated genetic,
cell and molecular tools are being used to investigate how proteoglycans contribute
to signaling activity, and how they regulate the movement and distribution
of the signaling molecules.


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Selected Publications:

Kirkpatrick, C.A., S.M. Knox, W.D. Staatz, B. Fox, D.M. Lercher and S.B. Selleck (2006) "The function of a Drosophila glypican does not depend entirely on heparan sulfate modification" Dev. Biol. 300:570-582.

Kirkpatrick, C.A., B.D. Dimitroff, J.M. Rawson & S.B. Selleck (2004) "Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein" Dev. Cell 7: 513-523.

*Simcha, I., *C. Kirkpatrick, E. Sadot, M. Shtutman, G. Polevoy, B. Geiger, M. Peifer and A. Ben-Ze’ev (2001) "Cadherin sequences that inhibit ß-catenin signaling: a study in yeast and mammalian cells" Mol. Biol. Cell, 12:1177-1188. (*contributed equally)

McCartney, B.M., *H.A. Dierick, *C. Kirkpatrick, M.M. Moline, A. Baas, M. Peifer and A. Bejsovec (1999) "Drosophila APC2 is a cytoskeletally-associated protein that regulates Wingless signaling in the embryonic epidermis" J. Cell Biol., 146: 1303-1318. (*contributed equally)

Cox, R.T., L.-M. Pai, C. Kirkpatrick, J. Stein and M. Peifer (1999) "The role of the C-terminus of Armadillo in Wingless signaling in Drosophila" Genetics 153: 319-332.

van Es, J.H., C. Kirkpatrick, M. van de Wetering, M. Molenaar, A. Miles, J. Kuipers, O. Destree, M. Peifer and H. Clevers (1999) "A homologue of the Adenomatous Polyposis Coli tumour suppressor" Curr. Biol. 9: 105-108.

Pai, L.-M., *C. Kirkpatrick, J. Blanton, H. Oda, M. Takeichi and M. Peifer (1996) "a-catenin and DE-cadherin occupy distinct binding sites on Drosophila Armadillo that differ substantially in size" J. Biol. Chem. 271: 32411-32420. (*contributed equally)

Cox, R., C. Kirkpatrick and M. Peifer (1996) "Armadillo is required for adherens junction assembly, cell polarity and morphogenesis during Drosophila embryogenesis" J. Cell Biol. 134: 133-148.

Kirkpatrick, C. and M. Peifer (1995) "Not just glue: cell-cell junctions as cellular signaling centers" Curr. Opin. Genet. Dev. 5: 56-65.


To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed

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 Last modified on Wednesday, December 20, 2006