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Paul Magee, Ph.D.

Professor

Mailing Address:
University of Minnesota
Department of Genetics, Cell Biology, and Development
6-160 Jackson
321 Church St. SE
Minneapolis, MN 55455
USA
Education:
Ph. D., University of California Berkeley, 1964
Yale College, BS, 1959
Office:
6-126 MCB
P: 612-624-7280

Email:
magee@umn.edu

 Lab:
6-178 MCB
P: 612-625-4732

Areas of Research Strength:

Optical mapping
STS mapping
Contour-clamped electric field pulse-field gel electrophoresis (CHEF)
molecular biology.

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Research Techniques:

Pulse-field gel electrophoresis

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Research Interests:

The Magee laboratory has been one of the leaders in characterizing the genome
of the human commensal/pathogenic fungus, Candida albicans. They study the
chromosome organization, chromosome dynamics, and the phenotypic consequences
of these phenomena. They are also helping to match the emerging sequence of the
related fungus, Candida dubliniensis, to the karyotype.


B.B. Magee has recently developed a mating system in this
nominally asexual yeast and has shown that many of the genes
involved in mating in Saccharomyces cerevisiae are also required
for mating in Candida. The alpha pheromone, a molecule involved
in signaling between cells of different mating types, has been
identified. A significant fraction of clinical isolates is
homozygous for the mating type locus and is able to mate. The
significance of mating in infection is under investigation.

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Selected Publications:

Chibana, H,, N.Oka, H. Nakayama, T. Aoyama, B.B. Magee, P.T. Magee, and Y. Mikami. 2005. Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics: 170: 1525-1537.

Ibrahim, A. S., B.B. Magee, D.C. Shephard, Molly Yang, Sarah Kaufman, Jeff Becker, John S. Edwards, jr, and P.T. Magee. 2005. Effect of ploidy and mating type on virulence in Candida albicans. Inf. Imm. 73: 7366-7374.

Lephart P, H Chibana, and PT Magee (2005). Effect of the major repeat sequence (MRS) on chromosome loss in Candida albicans. Eukarot Cell 4:733-741.

Forche A, G May, and PT Magee (2005). Demonstration of loss of heterozygosity by single-nucleotide polymorphism microaray analysis and alterations in strain morphology in Candida albicans strains during infection. Eukaryot Cell. 4: 156-65.

Panwar, S., M. Legrande, D. Dignard, M. Whiteway, and P.T. Magee. 2003. MFalpha1, the gene encoding the alpha mating pheromone of Candida albicans. Eukaryot Cell. 2:1350-60.

Xi Chen, B B Magee, Dean Dawson, PT Magee, Carol A, Kumamoto. 2004. Chromosome trisomy compromises the virulence of Candida albicans Mol. Microbiol.51:551-65.

Legrand, M. P. Lephart, A. Forche, F.M. Mueller, T. Walsh, P.T. Magee and B.B. Magee. 2004. Homozygosity at the MTL locus in Candida albicans: karyotypic rearrangements and tetraploid formation. Molecular Microbiol. 52: 1451-1462

Forche, A., P.T. Magee, B.B. Magee, and G. May.2004. Development of a genome-wide SNP map for Candida albicans. Eukaryot. Cell 3: 705-714

Jones, Ted, Nancy A. Federspiel , Hiroji Chibana, Jan Dungan, Sue Kalman, B. B. Magee, George Newport, Yvonne R. Thorstenson, Nina Agabian, P. T. Magee, Ronald W. Davis, and Stewart Scherer. 2004. The diploid genome sequence of Candida albicans. Proc. Nat. Acad. Sci. USA 101: 7329-34

Iwaguchi S, Suzuki M, Sakai N, Nakagawa Y, Magee PT, and Suzuki T. 2004 . Chromosome translocation induced by the insertion of the URA blaster into the major repeat sequence (MRS) in Candida albicans. Yeast. 21:619-34.

Forche A, May G, Magee PT. 2005. Demonstration of Loss of Heterozygosity by Single-Nucleotide Polymorphism Microarray Analysis and Alterations in Strain Morphology in Candida albicans Strains during Infection.Eukaryot Cell. 4:156-65

Magee PT, Magee BB. 2004.Through a glass opaquely: the biological significance of mating in Candida albicans.Curr Opin Microbiol. 7:661-5



To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed
search menu should say PubMed
type Magee PT in the available line

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 Last modified on Thursday, July 27, 2006