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Return to: College of Biological Sciences: Medical School: U of M Home |
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Areas of Research Strength: Molecular analysis of albinism Analysis of complex genetic disorders back to top |
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Research Techniques: STRP genotyping SNP analysis DNA sequencing back to top |
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Research Interests: Dr. Oetting's research focuses on the genetic analysis of common diseases. His major research is identifying genetic variants associated with adverse outcomes in solid organ transplantation. This work is includes using a high density SNP chip for association studies. My research in transplantation also includes proteomic analysis of urine to identify biomarkers associated with different clinical outcomes. Dr. Oetting is also interested in determining variants associated with susceptibility to asthma. The lab has identified several loci associated with asthma in families and we are currently mapping theses asthma susceptibility genes. Dr. Oetting is the director of the DNA analysis core facility of the General |
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Selected Publications: Argikar UA, Cloyd JC, Birnbaum AK, Leppik IE, Conday J, Kshirsagar S, Oetting WS, Klein EC, Remmel RP, 2006, .Parodoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients. Epilepsy Res. (in press). Cotton RGH, Auerbach AD, Oetting WS. 2006, Reply to Dr. Strom. Genetics in Medicine 8:459. Oetting WS, Rogers TB, Krick TP, Matas AJ, Ibrahim H. 2006, β2-microglobulin is a urine biomarker associated with acute kidney allograft rejection. American Journal of Kidney Disease 47:898-904 Jackola DR, Basu S, Liebeler CL, Willaert R, Luah SS, Oetting W, King RA, Blumenthal MN. . 2006, Inheritance of CD14 promoter polymorphisms in atopic families: Implications for modulated allergen-specific IgE and IgG1 responses. International Archives of Allergy & Immunology 139:217-24. Cotton RGH, Auerbach AD, Oetting WS. 2005, A call for mutations. Genetics in Medicine 7:370. Oetting WS, Garrett SS, Brott M, King RA, 2005, P gene mutations associated with oculocutaneous albinism type II (OCA2). Human Mutation 25:323. (Mutation in Brief #789 (2005) Online) http://www3.interscience.wiley.com/homepages/38515/pdf/789.pdf Young TL, Deeb SS, Ronan SM, Dewan AT, Alvear AB, Scavello GS, Paluru PC, Brott MS, Hayashi T, Holleschau AM, Benegas N, Schwartz M, Atwood LD, Oetting WS, Rosenberg T, Motulsky AG, King RA (2004) X-linked high myopia associated with cone dysfunction. Arch Ophthalmol 122:897-908. Blumenthal MN, Ober C, Beaty TH, Bleeker ER, Langefeld CD, King RA, Cox N, Mathias R, Meyers DA, Oetting W, Rich SS for the CSGA (2004) Genome scan for mite sensitivity. The Collaborative Study on the Genetics of Asthma (CSGA) Genes and Immunity 5:226-31. Thyagarajan B, Gross M, Folsom AR, Anderson K, Oetting WS, Brott M (2004) Association of CYP1B1 and CYP19 gene polymorphisms with breast cancer incidence. Cancer Letters 207:183-189. Reish O, Berryman T, Cunningham TC, Sher C, Oetting WS (2004) Analysis of Family with Two Dauthers Affected with Trisomy-X. Chromosome Research 12:125-132. Blumenthal MN, Langefeld CD, Beaty TH, Bleeker ER, Ober C, Lester L, Lange E, Barnes KC, Wolf R, King RA, Solway J, Oetting W, Meyers DA, Rich SS for the NHLBI Collaborative Study on the Genetics of Asthma (2004) A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Geetics of Asthma (CSGA). Human Genetics 114:157-64 Fryer JP, Oetting WS, King RA (2003) Identification and characterization of a DNase hypersensitive region of the human tyrosinase gene. Pigment Cell Research 16:679-684. King RA, Pietsch J, Fryer JP, Savage S, Brott MJ, Russel-Eggitt I, Summers CG, Oetting WS (2003) Tyrosinase gene mutations in oculocutaneous albinism (OCA1): Definition of the phenotype. Human Genetics 113:502-13. King RA, Willaert RK, Schmidt RM, Pietsch J, Savage S, Brott MJ, Fryer JP, Summers CG, Oetting WS (2003) MC1R mutations modify the classic phenotype of oculocutaneous albinism type 2 (OCA2). American Jounal of Human Genetics. 73:638-645. Oetting WS, Fryer JP, Shiriam S, King RA. Oculocutaneous albinism type I: The last 100 years. Pigment Cell Research 16:307-11. Oetting WS, 2002 New insight into Ocular Albinism Type 1 (OA1):Mutations and polymorphisms of the OA1 gene. Human Mutation 19:85-92 Fryer JP, Oetting WS, Brott MJ, King RA. 2001, Alternative splicing of the tyrosinase gene transcript in normal human melanocytes and lymphocytes. Journal of Investigative Dermatology 117:1261-1265. Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, Xu JF, Solway J, Barnes KC, Pierce J, Stine OC, Togias A, Oetting W, Marshik PL, Hetmanski JB, Huang SK, Ehrlich E, Dunston GM, Malveaux F, Banks-Schlegel S, Cox NJ, Bleecker E, Ober C, Beaty TH, Rich SS, 2001, Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families. Genetic Epidemiology 20:340-55. Oetting WS, Armstrong C, Holleschau A, DeWan AT, Summers CG, 2000, Evidence for genetic heterogenity in families with congenital motor nystagmus (CN). Ophthalmic Genetics 21:227-233. Oetting WS, 2000, The tyrosinase gene and oculocutaneous albinism type I (OCA1): A model for understanding the molecular biology of melanin formation. Pigment Cell Research 13:320-325. Thompson J, Chen P-L, King RA, Rich SS, Oetting WS, Armstrong C, Folsom AR, Sellers TA, 2000, BRCA1 susceptibility markers, and postmenopausal breast cancer: The Iowa's Women Health Study. Cancer Epidemiology, Biomarkers & Prevention 9:507-511. Oetting WS. 2000, Gene Expression Analysis. Pigment Cell Research 13:21-27. Oetting WS, 1999, Albinism. Current Opinion in Pediatrics 11:565-71. Sellers TA, King RA, Cerhan JR, Chen P-L, Grabrick DM, Kushi LH, Oetting WS, Vierkant RA, Vachon CM, Couch FJ, Therneau TM, Olson JE, Pankratz S, Hartmann LC, Anderson VE, 1999 Fifty year follow-up of cancer incidence in a historical cohort of Minnesota breast cancer families. Cancer Epidemiology, Biomarkers & Prevention 8:1051-1057. Tripathi RK, Flanders DJ, Young TL, Oetting WS, Ramaiah A, King RA, Boissy RE, Nordlund JJ, 1999, Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: An evaluation. Pigment Cell Research 12:187-192. Oetting WS, Fryer JA, Wyman Z, Shtorch A, Cordoba M, Lazarov A, Reish O, 1999, Molecular analysis of an extended Palestinian family with monilethrix. Genetics in Medicine 1: 109-111. Wildenberg SC, Fryer JP, Oetting WS, King RA. 1999, Three novel polymorphisms in the gene responsible for the Hermansky-Pudlak syndrome. Human Mutation 13:174, http://journals.wiley.com/1059-7794/pdf/mutation/mpr37.pdf. Oetting WS, King RA. 1999, Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism. Human Mutation 13:99-115. To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed search menu should say PubMed type Oetting WS in the avaliable line back to top |
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Related Links: General Clinical Research Center http://www.gcrc.umn.edu/gcrc/index.php?m=services&b=mg Albinism Database - International Albinism Center, University of Minnesota http://www.cbc.umn.edu/tad back to top |
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