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Return to: College of Biological Sciences: Medical School: U of M Home |
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Areas of Research Strength: craniofacial development bone biology mammalian embryogenesis organogenesis brain development back to top |
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Research Techniques: mouse knockouts molecular biology back to top |
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Research Interests: Research in the laboratory of Dr. Petryk focuses on mammalian development and the molecular mechanisms underlying tissue differentiation and organogenesis. In particular, the lab is interested in studying the role of BMP and Wnt signaling pathways in embryonic development and bone formation. One of BMP-binding proteins is Twisted gastrulation (Twsg1). Recent work has focused on the role of Twsg1 in craniofacial development using a mouse model with a targeted deficiency of the Twsg1 gene. The majority of Twsg1 mutants have abnormal morphogenesis of the first (mandibular) branchial arch (BA1), manifesting as hypoplastic or absent mandible, with variable degrees of accompanying craniofacial defects. Since a significant number of human craniofacial syndromes are the result of abnormal development of BA1, Twsg1-deficient mice serve as a model to study the molecular and cellular basis of defective BA1 patterning. back to top |
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Selected Publications: Carlson ES, Stead JD, Neal CR, Petryk A, Georgieff MK (2007) Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus. Hippocampus 17:679-691. Schleiffarth JR, Person AD, Martinsen BJ, Sukovich DJ, Neumann A, Baker CVH, Lohr JL, Cornfield DN, Ekker SC, Petryk A (2007) Wnt5a is required for cardiac outflow tract septation in mice. Pediatr Res 61: 386-391. Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O’Connor MB (2006) Spook and Spookier code for stage specific components of the ecdysone biosynthetic pathway in Diptera. Dev Biol 298: 555-570. Maes C, Coenegrachts L, Stockmans I, Daci E, Luttun A, Petryk A, Gopalakrishnan R, Moermans K, Smets N, Verfaillie CM, Carmeliet P, Bouillon R, Carmeliet G (2006) Placental growth factor is essential for mesenchymal cell development, cartilage turnover and bone remodeling during fracture repair. JCI 116: 1230-1242. Petryk A, Bergemann TL, Polga KM, Ulrich KJ, Raatz SK, Brown DM, Robison LL, Baker KS (2006) Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantation. JCEM 91: 899-905. Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T (2006) Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol 51: 433-438. Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC (2005) Wnt5a signaling in vertebrate pancreas development. BMC Biology 3:23. Parvy, J-P, Blais C, Bernard F, Warren J, Petryk A, Gilbert LI, O'Connor MB, Dauphin-Villemant C. (2005) A role for ßFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster. Dev Biol 282:84-94. Petryk A, Shimmi O, Jia X, Carlson A, Tervonen L, Jarcho MP, O’Connor MB, Gopalakrishnan R (2005) Twisted gastrulation and Chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells. Bone 36:617-626. Warren JT, Petryk A, Marqués G, Parvy J-P, Shinoda T, Itoyama K, Kobayashi J, Jarcho MP, Li Y, O'Connor MB, Dauphin-Villemant C, Gilbert LI (2004) Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis. Insect Biochem Mol Biol 34: 991-1010. Petryk A, Anderson RM, Jarcho MP, Leaf I, Carlson CS, Klingensmith J, Shawlot W, O'Connor MB (2004) The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol 267: 374-386. Petryk A, Warren JT, Marqués G, Jarcho MP, Gilbert LI, Kahler J, Parvy J-P, Li Y, Dauphin-Villemant C, O’Connor MB (2003) Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. PNAS 100: 13773-13778. Warren JT, Petryk A, Marqués G, Jarcho M, Parvy J-P, Dauphin-Villemant C, O’Connor MB, Gilbert LI (2002) Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster. PNAS 99: 11043-11048. Ross J, Shimmi O, Vilmos P, Petryk A, Kim H, Gaudenz K, Hermanson S, Ekker S, O'Connor MB, Marsh L (2001) Twisted gastrulation is a conserved extracellular BMP antagonist. Nature 410: 479-483. Petryk A, Fleenor D, Driscoll P, Freemark M (2000) Prolactin induction of insulin gene expression: The roles of glucose and glucose transporter-2. J Endocrinol 164: 277-286. To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed search menu should say PubMed type Petryk A in the avaliable line back to top |
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Related Links: http://www.ninds.nih.gov/health_and_medical/disorders/holoprosencephaly.htm http://www.sbaa.org/html/sbaa_facts.html back to top |
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